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SETSCI - Volume 3 (2018)
ISAS2018-Winter - 2nd International Symposium on Innovative Approaches in Scientific Studies, Samsun, Turkey, Nov 30, 2018

Investigation of anti-cancer properties of derivaties of 2- benzimidazole (ISAS2018-Winter_183)
Burak Tüzün1*, Sultan Erkan2
1Sivas Cumhuriyet University  , Sivas, Turkey
2Sivas Cumhuriyet University  , Sivas, Turkey
* Corresponding author: btuzun@cumhuriyet.edu.tr
Published Date: 2019-01-14   |   Page (s): 962-969   |    7     3

ABSTRACT Transition metal complexes are playing an important role the field of bioorganic chemistry. it has been
attempted to investigate the anti-cancer properties of complexes of 2-benzimidazole derivatives formed with
various metal atoms [1-2]. In these examinations, biological agents of these derivatives will be compared [3]. The
most active ligand will examine the complexes that this ligand creates with its metal atoms. Metal complexes are
useful in the development of effective drugs for various diseases like cancer. The ability of transition metal ions
to exhibit variable oxidation states has made them to be potential molecules in the biological system. Many of the
coordination complexes with copper and zinc have been established to be effective antibacterial, cytotoxic, antiinflammatory and antiviral agents. Optimized structures are calculated in B3lyp, HF and m062x, method 3-21g,
6-31g, sdd basis set.
The 1H-NMR, 12C-NMR, UV-VİS and IR spectra of these ligands will be examined by looking at their
spectroscopic properties. At the same time, Molecular docking calculations are carried out between studied ligand
and the 2ING is well known like the breast and ovarian cancer proteins at DockingServer. Anti-cancer properties
will be examined by the most optimized structures of ligands.  
KEYWORDS 2-benzimidazole, Molecular docking, DFT, spectroscopy
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