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SETSCI - Volume 3 (2018)
ISAS2018-Winter - 2nd International Symposium on Innovative Approaches in Scientific Studies, Samsun, Turkey, Nov 30, 2018

Production of 5-FU Drug Loaded Biocomposite Materials : Drug Loading Efficiency and Characterization (ISAS2018-Winter_284)
Nalan Erdöl Aydın1*, Ebru Kahraman2, Gülhayat Nasün Saygılı3
1İstanbul Technical University, İstanbul, Turkey
2İstanbul Technical University, İstanbul, Turkey
3İstanbul Technical University, İstanbul, Turkey
* Corresponding author: erdol@itu.edu.tr
Published Date: 2019-01-14   |   Page (s): 1499-1502   |    27     10

ABSTRACT Hydroxyapatite/polymer composites are promising materials for drug delivery applications. Studies focusing on the
development of such composites are available in recent years, as using these materials as a carrier allows us to overcome the
side affects of toxic drugs used especially in cancer treatments and increase treatment efficiency. In this study, hydroxyapatitechitosan (HAp-CTS) biocomposites are produced in the presence of simulated body fluid (SBF) as a carrier for 5-Fluorouracil
(5-FU). 5-FU, which is widely used for the treatment of colon, rectal, breast, ovary, pancreas, stomach, brain and skin cancer,
is selected as drug. Biocomposite materials are produced by wet precipitation method at pH 7.4 and 37°C implementing
glutaraldehyde (GA) as a cross-linking agent. Drug loading process is performed during the wet precipitation. In order to
observe the effect of GA amount on drug loading efficiency, composites cross-linked with different amounts of GA are
released in deinozed water, HCl and phosphate bufffer solution (PBS). Absorbance value of the solution was obtain by Uv-vis
(Jenway 6305) spectra and calibration curve was evaluated to calculate the drug concentrations. Composites are analyzed by
X-Ray Diffraction (XRD), Thermogravimetric Analyses (TGA), Scanning Electron Microscopy (SEM) and particle size
distribution to observe morphology and structure. It is concluded that drug loaded HAp-CTS composites have a potential to be
used in drug delivery applications.  
KEYWORDS Biocomposite material, hydroxyapatite, chitosan, polymer, drug loading
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