eISSN: 2618-6446
Latest Issue Archive Future Issues About Us JOURNALS

SETSCI - Volume 3 (2018)
ISAS2018-Winter - 2nd International Symposium on Innovative Approaches in Scientific Studies, Samsun, Turkey, Nov 30, 2018

Diyet Posası ve Kanser (ISAS2018-Winter_60)
Nural Erzurum Alim1*, Kaan Kerim Göküstün2
1Ankara Yıldırım Beyazıt University, Ankara, Turkey
2Ankara Yıldırım Beyazıt University, Ankara, Turkey
* Corresponding author: nalim@ybu.edu.tr
Published Date: 2019-01-14   |   Page (s): 317-321   |    19     5
ABSTRACT Kanser küresel olarak ölümlere neden olan ciddi bir halk sağlığı sorunudur. Bu sağlık sorununun nedenleri genetik (%5)
ve çevresel etmenler (%95) olarak iki gruba ayrılmaktadır. Çevresel etmenler arasında ise beslenme alışkanlıklarının kanser
oluşumunda önemli bir rolü vardır. Vitamin, mineral ve diyet posasından zengin meyve, sebze ve tam tahıllı ürünlerin
tüketiminin kanser oluşumunu önleyebileceği bildirilmiştir. Bu derlemede diyet posasının kanser üzerine etkilerinin incelenmesi
amaçlanmıştır. Diyet posası çözünür ve çözünmez posa bileşikleri olarak kategorize edilebilmektedir. Çözünür posa bileşikleri
kısa zincirli yağ asitlerinin oluşumunu sağlamakta, glutatyan-S-transferaz (GST) enzim aktivitelerini arttırmakta, siklooksijenaj-
2 (COX-2) ve nükleer faktör kappa beta (Nf-Kβ) aktivitelerini azaltmakta, gut ilişkili lenfoid doku (GALT) yanıtını
düzenlemektedir. Çözünmez posa bileşikleri ise kanserojen moleküllerin emilimini azaltarak, tümör hücrelerinin gelişimini
inhibe ederek kansere karşı koruyucu olabilmektedir. Sonuç olarak diyet posasının çeşitli mekanizmalar aracılığı ile kanser
gelişimini önleyebilmektedir. Ancak altta yatan mekanizma tam olarak açıklanamamıştır. Bu nedenden dolayı posa ile kanser
arasındaki ilişkinin daha iyi anlaşılabilmesi ve altta yatan mekanizmanın net bir şekilde belirlenebilmesi için daha çok çalışma
yapılmalıdır . 
KEYWORDS Kanser, çözünür posa, çözünmez posa, GALT, Nf-Kβ
REFERENCES [1] (2018) WHO website. [online]. Available: http://www.who.int/news-room/fact-sheets/detail/cancer
[2] F. Bray, J. Ferlay, I. Soerjomataram, R.L Siegel, L.A. Torre, and A. Jemal, ''Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries,'' A Cancer Journal for Clinicians., Vol. 0, pp. 1-31, 2018.
[3] R.B. Ruiz, and P.S. Hernández, ''Diet and cancer: risk factors and epidemiological evidence,'' Maturitas., Vol. 77, pp. 202-208, Mar. 2014.
[4] AAAC Report, ''The Definition of Dietary Fiber1,'' Vol. 46, pp. 112-126, Mar. 2001.
[5] A. Baysal, Beslenme, Ankara: Hatiboğlu Yayımcılık p. 363-371, 2012.
[6] K. S. Kalyani Nair, S. Kharb, and D. Thompkinson, ''Inulin dietary fiber with functional and health attributes—a review,'' Food Reviews International., vol. 26, pp.189-203, Mar. 2010.
[7] J. Slavin, ''Fiber and prebiotics: mechanisms and health benefits,'' Nutrients., Vol. 5, pp. 1417-1435, Jan. 2013.
[8] J.L. Slavin, V. Savarino, A. Paredes-Diaz, and G. Fotopoulos, ''A review of the role of soluble fiber in health with specific reference to wheat dextrin,'' Journal of International Medical Research., Vol. 37, pp. 1-17, Feb. 2009.
[9] G. Samur, and S.M. Mercanlıgil, Diyet posasi ve beslenme. The Ministry of Health of Turkey, The General Directorate of Primary Health Care, 2008.
[10] G.O. Phillips, ''Dietary fibre: A chemical category or a health ingredient?,'' Bioactive Carbohydrates and Dietary Fibre., Vol. 1, pp. 3-9, Jan. 2013.
[11] L.R. Jacobs, ''Relationship between dietary fiber and cancer: metabolic, physiologic, and cellular mechanisms,'' Proceedings of the Society for Experimental Biology and Medicine., Vol. 183, pp. 299-310, Dec. 1986.
[12] M.S. Farvid, A.H. Eliassen, E. Cho, X. Liao, W.Y. Chen and W.C. Willet, ''Dietary fiber intake in young adults and breast cancer risk,'' Pediatrics., Vol. 137, p. e20151226, Mar. 2016.
[13] J.M. Lattimer, and M.D. Haub, ''Effects of dietary fiber and its components on metabolic health,'' Nutrients., Vol. 2, pp. 1266-1289, Nov. 2010.
[14] Z. Zhang, G. Xu, N. Ma, J. Yang, and X. Liu, ''Dietary fiber intake reduces risk for gastric cancer: a meta-analysis,'' Gastroenterology., Vol. 145, pp. 113-120, Jul. 2013.
[15] E. Bidoli, C. Pelucchi, A. Zucchetto, E. Negri, L. Dal Maso, J. Polesel, et al., ''Fiber intake and pancreatic cancer risk: a case–control study,'' Annals of oncology., Vol. 23, pp. 264-268, Apr. 2011.
[16] K. Uchida, S. Kono, G. Yin, K. Toyomura, J. Nagano, T. Mizoue, et al., ''Dietary fiber, source foods and colorectal cancer risk: the Fukuoka Colorectal Cancer Study,'' Scandinavian journal of gastroenterology., Vol. 45, pp. 1223-1231, May. 2010.
[17] T.K. Asano, and R.S. McLeod, ''Dietary fibre for the prevention of colorectal adenomas and carcinomas,'' Cochrane database of systematic reviews., Jan. 2002.
[18] R.K.P. Purushothaman, F. van der Klis, A. E. Frissen, J. van Haveren, A. Mayoral, A. van der Bent, et al., ''Base-free selective oxidation of pectin derived galacturonic acid to galactaric acid using supported gold catalysts,''. Green Chemistry., May. 2018.
[19] W. Zhang , P. Xu, and H. Zhang, ''Pectin in cancer therapy: a review,'' Trends in Food Science & Technology., Vol. 44, pp. 258-271, Aug. 2015.
[20] S. Umar, A. P. Morris, F. Kourouma, and J. H. Sellin, ''Dietary pectin and calcium inhibit colonic proliferation in vivo by differing mechanisms,'' Cell proliferation., Vol. 36, pp. 361-375, Nov. 2003.
[21] N. Thombare, U. Jha, S. Mishra, and M.Z. Siddiqui, ''Guar gum as a promising starting material for diverse applications: A review,'' International journal of biological macromolecules., Vol. 88, pp. 361-372, Jul. 2016.
[22] A.P. Nugent, ''Health properties of resistant starch,'' Nutrition Bulletin., Vol. 30, pp. 27-54, Feb. 2005.
[23] M.G. Sajilata, R.S. Singhal, and P.R. Kulkarni, ''Resistant starch– a review,'' Comprehensive reviews in food science and food safety., Vol. 5, pp. 1-17, Nov. 2006.
[24] M.J.A.L. Grubben, C.C.M. van den Braak, M. Essenberg, M. Olthof, A. Tangerman, M.B. Katan, et al., ''Effect of resistant starch on potential biomarkers for colonic cancer risk in patients with colonic adenomas,'' Digestive diseases and sciences., Vol. 46, pp. 750-756, Apr. 2001.
[25] M.L. Heijnen, J. M van Amelsvoort, P. Deurenberg, and A. C Beynen, ''Limited effect of consumption of uncooked (RS2) or retrograded (RS3) resistant starch on putative risk factors for colon cancer in healthy men,'' The American journal of clinical nutrition., Vol. 67, pp. 322-331, Feb. 1998. 67(2): p. 322-331.
[26] M.B. Roberfroid, ''Introducing inulin-type fructans,'' British Journal of Nutrition., Vol. 93, pp.13-25, Mar. 2005.
[27] J.L. Causey, J.M. Feirtag, D.D. Gallaher, B.C. Tungland, and J.L. Slavin, ''Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolemic men,''. Nutrition Research., Vol. 20, pp. 191-201, Feb. 2000.
[28] E. Hijova , V. Szabadosova , L. Strojny, and A. Bomba ''Changes chemopreventive markers in colorectal cancer development after
inulin supplementation,'' Bratislavske lekarske listy., Vol. 115, pp. 75-79, Jan. 2014.
[29] M. Verghese, D. R. Rao, C. B. Chawan, and L. Shackelford, ''Dietary inulin suppresses azoxymethane-induced preneoplastic aberrant crypt foci in mature Fisher 344 rats,'' The Journal of nutrition., Vol. 132, pp. 2804-2808, Sep. 2002.
[30] N. Kaur, and A.K. Gupta, ''Applications of inulin and oligofructose in health and nutrition,'' Journal of biosciences., Vol. 27, pp. 703- 714, Sep. 2002.
[31] H.S.Taper, and M. Roberfroid, ''Influence of inulin and oligofructose on breast cancer and tumor growth,'' The Journal of nutrition., Vol. 129, pp. 1488-1419, Jul. 1999.
[32] N. Yabancı, ''İnülin ve oligofruktozların insan sağlığı ve beslenmesi üzerine etkileri,'' Akademik Gıda., Vol. 8, pp. 49-54, 2010.
[33] F.R. Bornet, K. Meflah, and J. Menanteau, ''Enhancement of gut immune functions by short-chain fructooligosaccharides and reduction of colon cancer risk,'' Bioscience and microflora., Vol. 21, pp. 55-62, 2002.
[34] M. Deschasaux, C. Pouchieu, M. His, S. Hercberg, P. Latino Martel, and M. Touvier, ''Dietary Total and Insoluble Fiber Intakes Are Inversely Associated with Prostate Cancer Risk–3,'' The Journal of nutrition., Vol. 144, pp. 504-510, Feb. 2014.
[35] P. Terry, J. Lagergren, W. Ye, A. Wolk, and O. Nyren, ''Inverse association between intake of cereal fiber and risk of gastric cardia cancer,'' Gastroenterology., Vol. 120, pp. 387-391, Feb. 2001.
[36] M.A. Mendez, G. Pera, A. Agudo, H. Bas Bueno‐de‐Mesquita, D. Palli, H. Boeing, et al., ''Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC‐EURGAST study,'' International journal of cancer., Vol. 121, pp. 1618-1623, Jun. 2007.
[37] A.T. Kunzmann, H.G. Coleman, WY. Huang, C.M. Kitahara, M.M. Cantwell, and S.I. Berndt, ''Dietary fiber intake and risk of colorectal cancer and incident and recurrent adenoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, 2,'' The American journal of clinical nutrition., Vol. 102, pp. 881-
890, Aug. 2015.
[38] L. Sun, Z. Zhang, J. Xu, G. Xu, and X. Liu ''Dietary fiber intake reduces risk for Barrett's esophagus and esophageal cancer,'' Critical reviews in food science and nutrition., Vol. 57, pp. 2749- 2757, Oct. 2015.
[39] Q. Li, T.R. Holford, Y. Zhang, P. Boyle, S.T. Mayne, M. Dai, et al., ''Dietary fiber intake and risk of breast cancer by menopausal and estrogen receptor status,'' European journal of nutrition., Vol. 52, pp. 217-223, Feb. 2013.
[40] B.Tungland, and D. Meyer, ''Nondigestible oligo‐and polysaccharides (Dietary Fiber): their physiology and role in human health and food,'' Comprehensive reviews in food science and food safety., Vol. 1, pp. 90-109, Nov. 2006.
[41] P.Y. Cheah, and H. Bernstein, ''Colon cancer and dietary fiber: Cellulose inhibits the DNA‐damaging ability of bile acids,'' Journal of Nutrition and Cancer., Vol. 13, 1990.
[42] D. Mudgil, and S. Barak, ''Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: a review,'' International journal of biological macromolecules., Vol. 61, pp. 1-6, Oct. 2013.
[43] D. Dhingra, M. Michael, H. Rajput, and R.T. Patil ''Dietary fibre in foods: a review,'' Journal of food science and technology., Vol. 49, pp.255-266, Jun. 2012.
[44] J.L. Slavin, ''Mechanisms for the impact of whole grain foods on cancer risk,'' Journal of the American College of Nutrition., Vol. 19, pp. 300-307, Feb. 2000.
[45] H. Qu, R.L. Madl, D.J. Takemoto, R.C. Baybutt, and W. Wang ''Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells,'' The Journal of nutrition., Vol. 135, pp. 598-602, Mar. 2005.
[46] S. Fuller, E. Beck, H. Salman, and L. Tapsell ''New horizons for the study of dietary fiber and health: a review,'' Plant foods for human nutrition., Vol. 71, pp. 1-12, Mar. 2016.
[47] J.L. Adolphe, S.J. Whiting, B. H. J. Juurlink, and L.U. Thorpe, ''Health effects with consumption of the flax lignan secoisolariciresinol diglucoside,'' British Journal of Nutrition., Vol. 103, pp. 929-938, Apr. 2010.
[48] F. Boccardo, G. Lunardi, P. Guglielmini, M. Parodi, R. Murialdo, G. Schettini, et al., F., ''Serum enterolactone levels and the risk of breast cancer in women with palpable cysts,'' European journal of cancer., Vol. 40, pp. 84-89, Jan. 2004.
[49] D .Li, J.A. Yee, L.U. Thompson, and L. Yan, ''Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice,'' Cancer letters., Vol. 142, pp. 91-96, Jul. 1999.
[50] K.P. Tan, J. Chen, W.E. Wand, and L.U. Thompson, ''Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats,'' Experimental Biology and Medicine., Vol. 229, pp. 147-157, Feb. 2004.
[51] P. Pietinen, K. Stumpf, S. Männistö, V. Kataja, M. Uusitupa, and H. Adlercreutz ''Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland,'' Cancer Epidemiology and Prevention Biomarkers., Vol. 10, pp. 339-344, Apr. 2001. 10(4): p. 339-344.
[52] L.-Q. Wang, ''Mammalian phytoestrogens: enterodiol and enterolactone,'' Journal of Chromatography B., Vol. 777, pp. 289-309, Sep. 2002.
[53] H. Liu, J. Liu, S. Wang, Z. Zeng, T. Li, Y. Liu, et al., ''Enterolactone has stronger effects than enterodiol on ovarian cancer,'' Journal of ovarian research., Vol. 10, pp. 49, Jul. 2017.
[54] A. Kilkkinen, J. Virtamo, E. Vartiainen, R. Sankila, M.J. Virtanen, H. Adlercreutz, et al., ''Serum enterolactone concentration is not associated with breast cancer risk in a nested case‐control study,'' International journal of cancer., Vol. 108, pp. 277-280, Oct. 2003.
[55] (2016) Food and Nutrition Board, Institute of Medicine, National Academies website [online]. Avaible:
http://www.nationalacademies.org/hmd/~/media/Files/Activity%20Files/Nutrition/DRITables/5Summary%20TableTables%2014.pdf?la=en
[56] Ed. G. Pekcan, N. Şanlıer, and M. Baş, Türkiye Beslenme Rehberi 2015 (TÜBER), 2016: Ankara.
[57] B. Yao, H. Fang, W. Xu, Y. Yan, H. Xu, Y. Liu, et al., ''Dietary fiber intake and risk of type 2 diabetes: a dose–response analysis of prospective studies,'' Springer., Vol. 29, pp. 79-88, Feb. 2014,.
[58] S. Ötles, and S. Ozgoz, ''Health effects of dietary fiber,'' Acta scientiarum polonorum technologia alimentaria., Vol. 13, pp. 191-202, 2014.
[59] P. Mirmiran, Z. Bahadoran, S.K. Moghadam, A.Z. Vakili, and F. Azizi, ''A prospective study of different types of dietary fiber and risk of cardiovascular disease: tehran lipid and glucose study,'' Nutrients., Vol. 8, pp. 686, Aug. 2016.
[60] Q. Ben, Y. Sun, R. Chai, A. Qian, B. Xu, and Y. Yuan, ''Dietary fiber intake reduces risk for colorectal adenoma: a meta-analysis,'' Gastroenterology., Vol. 146, pp. 689-699, Mar. 2014.

SET Technology - Turkey
eISSN  : 2618-6446

E-mail : info@set-science.com
+90 533 2245325

Tokat Technology Development Zone Gaziosmanpaşa University Taşlıçiftlik Campus, 60240 TOKAT-TURKEY
©2018 SET Technology