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SETSCI - Volume (2018)
ISAS 2018 - Ist International Symposium on Innovative Approaches in Scientific Studies, Kemer-Antalya, Turkey, Apr 11, 2018

A Functionalized-Gold Nanoparticles Based Optical Nanosensor for Biomolecule Detection (ISAS 2018_136)
Nisa Bekar1*, Kübra Soğancı2, İlker Akın3, Haluk Bingöl4, Erhan Zor5
1Department of Nanoscience and Nanoengineering, Institute of Science, Necmettin Erbakan University , Konya, Turkey
2Department of Nanoscience and Nanoengineering, Institute of Science, Necmettin Erbakan University, Konya, Turkey
3Department of Biotechnology, Faculty of Science, Necmettin Erbakan University , Konya, Turkey
4KimyaÖğretmenliği Anabilim Dalı, Ahmet Keleşoğlu Eğitim Fakültesi, Necmettin Erbakan Üniversitesi , Konya, Turkey
5Fen Bilgisi Öğretmenliği Anabilim Dalı, Ahmet Keleşoğlu Eğitim Fakültesi, Necmettin Erbakan Üniversitesi , Konya, Turkey
* Corresponding author: bekarnisa@gmail.com
Published Date: 2018-06-23   |   Page (s): 146-146   |    63     4

ABSTRACT Over the past decade, gold nanoparticles (AuNPs) have stimulated great interest in various types of sensors because
they possess many attractive properties such as optical, electronic and chemical features [1]. In order to gain more intrinsic
properties and much more selectivity, the surface of AuNPs is functionalized by selective groups/macromolecules. In this regard,
cyclodextrins (CD) are known as capable module units to host various molecules. Taking advantage of AuNPs and β-CD, we
herein report an optical nanosensor for sensing of amino acid enantiomers. To this aim, we synthesized β-cyclodextrin
functionalized gold nanoparticles (βCD@AuNPs) by reduction of HAuCl4 in the presence of β-CD. Within this respect, the
prepared solutions of β-CD and HAuCl4 were mixed at room temperature to give a clear solution. Then the resultant was heated
at 100 °C and stirred for 4 h leading to the formation of Au nanoparticles. The color turned to red wine proving the formation of
AuNPs [2]. To prove the settlement of β-CDs on AuNPs, the structural characterization of β-CD@AuNPs was performed by FTIR and UV-Vis spectroscopy, and compared to bare β-CD and AuNPs. The sensor performance was evaluated by following the
colour change in the presence of the tested bioactive molecules (herein, proline, phenylalanine, leucine, thereonine, valine,
glutamine, tartaric acid, serine, mandelic acid, methionine, alanine, cystine, tryptophan, tyrosine, histidine, arginine, lysine were
tested as model analytes) in solution. The results show that β-CD@AuNPs exhibits different affinity and this nanosensor can
pave the way for selective detection of the other biomolecules.  
KEYWORDS Gold nanoparticles, nanosensor, amino acid enantiomers
REFERENCES [1] Zor, E. and Bekar, N., Biosens. Bioelectron. 2017, 91, 211–216.
[2] Huang, T. et al., J. Phys. Chem. C 2009, 113, 13636–13642.

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