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SETSCI - Volume 4 (9) (2019)
ISAS WINTER-2019 (HSS) - 4th International Symposium on Innovative Approaches in Health and Sports Sciences, Samsun, Turkey, Nov 22, 2019

Role of Efflux Pump in Biofilm Formation of Multidrug-Resistant Pseudomonas aeruginosa
Ceren Başkan1*, Belgin Sırıken2
1Amasya University, Amasya, Turkey
2Ondokuz Mayıs University, Samsun, Turkey
* Corresponding author: cerennyavuz@hotmail.com
Published Date: 2019-12-23   |   Page (s): 131-135   |    138     5
https://doi.org/10.36287/setsci.4.9.081

ABSTRACT Pseudomonas (P.) aeruginosa is Gram-negative an opportunistic human pathogen associated with nosocomial infections particularly immuno-compromised patients such as cystic fibrosis, cancer, and diabetes. This organism can also develop high-level intrinsic and acquired antibiotic resistance by different mechanisms when it grows in a biofilm. The formation of biofilm, known as a passive resistance mechanism, inhibits the diffusion of antibiotics due to the polysaccharide structure surrounding the bacteria and makes the bacteria resistant. One of the most important mechanisms responsible for multiple antimicrobial resistance in biofilm structures is the efflux pump. Five families of bacterial drug efflux pumps have been identified that contribute to the efflux pathways including the ATP binding cassette (ABC) family, major facilitator superfamily (MFS), the multidrug and toxin extrusion (MATE) family, the small multidrug resistance (SMR), the resistance nodulation cell division (RND) superfamily. Among these pumps, the RND efflux pumps in P. aeruginosa play a major role in MDR. Furthermore, there are 11 types of RND efflux pumps in P. aeruginosa for the release of multi-class drugs. Of these, MexAB-OprM, MexCD-OprJ, MexEF-OprN and MexXY are most important due to their high prevalence in clinical strains. In summary this review focus on the aim to give an overview of the relationship between efflux mediated resistance and biofilm formation in bacteria.
KEYWORDS Pseudomonas aeruginosa, multidrug resistance, biofilm formation, efflux pump
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